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Rabbit Anti-HOXc8  antibody (bs-0394R)  
~~~促銷,代碼KT202502A~~~
~~~促銷,代碼KT202502B~~~
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產(chǎn)品編號 bs-0394R
英文名稱 Rabbit Anti-HOXc8  antibody
中文名稱 HOXc8抗體
別    名 Hox-3.1; Homeo box 3A; Homeo box 8; Homeobox 3A; Homeobox C8; Homeobox protein Hox C8; Homeobox protein Hox-C8; Homeobox protein HoxC8; Homeobox protein R4; Homolog of mouse Hox 3.1; HOX 3; Hox 3.1 mouse homolog of; HOX 3A; HOX C8; Hox-3.1, MOUSE, HOMOLOG OF; Hox-3A; HOX3; HOX3A; HOXC 8; Hoxc-8; M31; HXC8_HUMAN.  
研究領(lǐng)域 免疫學(xué)  神經(jīng)生物學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Rat (predicted: Mouse,Pig,Cow,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 27kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HOXc8: 51-130/242 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders.

Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subunit:
Interacts with SMAD1 and HOMEZ.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the Antp homeobox family.
Contains 1 homeobox DNA-binding domain.

SWISS:
P31273

Gene ID:
3224

Database links:

Entrez Gene: 607052 Dog

Entrez Gene: 3224 Human

Entrez Gene: 15426 Mouse

Omim: 142970 Human

SwissProt: P31273 Human

SwissProt: P09025 Mouse

Unigene: 664500 Human

Unigene: 6167 Mouse



HOXc8基因是HOX基因家族中的一員,研究小鼠中HOXc8蛋白的位置、結(jié)構(gòu)以及HOXc8蛋白在小鼠胚胎發(fā)育中的表達(dá)與調(diào)控、小鼠神經(jīng)系統(tǒng)的發(fā)育均已被廣泛重視.
HOXc8蛋白的表達(dá)對APP基因的表達(dá)有抑制作用,有學(xué)者認(rèn)為HOXc8基因可能與Alzheimer's病的發(fā)病有關(guān).
目前對哺乳動物同源盒基因在中樞神經(jīng)系統(tǒng)發(fā)育中的廣泛表達(dá)以及在胚胎發(fā)育中的區(qū)域特異性表達(dá)方式被認(rèn)為是非常重要的,已引起科學(xué)家們的廣泛重視。
產(chǎn)品圖片
Sample: Brain(Rat) lysate at 30ug; Liver(Rat) lysate at 30ug; Primary: Anti-HOXc8 (bs-0394R) at 1:200; Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bse-0295G) at 1: 3000; Predicted band size : 27kD Observed band size : 27kD, 43kD
Sample: Liver(Rat) Lysate at 40 ug Primary: Anti-HOXc8 ? (bs-0394R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 27 kD Observed band size: 27 kD
Paraformaldehyde-fixed, paraffin embedded (Human cervical cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Histone H3) Polyclonal Antibody, Unconjugated (bs-0394R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Human cervical cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Hox-3.1) Polyclonal Antibody, Unconjugated (bs-0394R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
Paraformaldehyde-fixed, paraffin embedded Rat small intestine; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer normal goat serum at 37°C for 30min; Antibody incubation with (Hox-3.1) Polyclonal Antibody, Unconjugated (bs-0394R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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