| 產(chǎn)品編號(hào) | bs-0987R |
| 英文名稱 | Butyrylcholinesterase Rabbit pAb |
| 中文名稱 | 丁酰膽堿酯酶抗體 |
| 別 名 | Acylcholine acylhydrolase; Choline esterase II; CHE1; Butyrylcholine esterase; Pseudocholinesterase; BchE; CHLE_HUMAN. |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 新陳代謝 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Rabbit,Pig,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 66 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human BCHE: 505-602/602 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage. [provided by RefSeq, Jul 2008]. Function: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. Subunit: Homotetramer; disulfide-linked. Dimer of dimers. Subcellular Location: Secreted. Tissue Specificity: Detected in blood plasma (at protein level). Present in most cells except erythrocytes. DISEASE: Butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]: Metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the type-B carboxylesterase/lipase family. SWISS: P06276 Gene ID: 590 Database links: Entrez Gene: 590 Human Omim: 177400 Human SwissProt: P06276 Human Unigene: 420483 Human 丁酰膽堿酯酶Bche又稱假性膽堿酯酶。該酶主要分布于腦白質(zhì)（中腦，橋腦，延腦，紋狀體及丘腦等腦干區(qū)域），也分布于心血管系統(tǒng)、呼吸系統(tǒng)、消化系統(tǒng)等組織及腺體中，專一性水解丁酰膽堿酯而發(fā)揮其生理功能。目前有用于老年癡呆AD病方面的的研究。 （脊椎動(dòng)物體內(nèi)有兩種膽堿酯酶：乙酰膽堿酯酶AchE，又叫真性膽堿酯酶。該酶不僅存在于膽堿能神經(jīng)，也存在于非但堿能神經(jīng)及其他組織，如胎盤(pán)、紅細(xì)胞等，專一水解Ach；在一種就是丁酰膽堿酯酶Bche） |
| 產(chǎn)品圖片 |
Sample: Hela Cell Lysate at 30 ug
Primary: Anti- BCHE(CT) (bs-0987R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/10000 dilution
Predicted band size: 66 kD
Observed band size: 63 kD
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