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Rabbit Anti-FPRL1  antibody (bs-3654R)  
~~~促銷,代碼KT202502A~~~
~~~促銷,代碼KT202502B~~~
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產(chǎn)品編號 bs-3654R
英文名稱 Rabbit Anti-FPRL1  antibody
中文名稱 脂氧素受體1抗體
別    名 ALXR; FMLP R I; FMLP R II; FMLP related receptor I; FMLP-R-I; FMLP-R-II; FMLP-related receptor I; FMLPX; Formyl peptide receptor 2; Formyl peptide receptor like 1; Formyl peptide receptor related; Formyl peptide receptor-like 1; FPR 2; FPR2; FPR2_HUMAN; FPR2A; FPRH 1; FPRH 2; FPRH1; FPRH2; FPRL 1; FPRL1; HM63; Lipoxin A4 receptor; LXA4 receptor; LXA4R; N-formyl peptide receptor 2; RFP.  
Specific References  (4)     |     bs-3654R has been referenced in 4 publications.
[IF=8.702] Cao Yirui. et al. Formyl peptide receptor 2 activation by mitochondrial formyl peptides stimulates the neutrophil proinflammatory response via the ERK pathway and exacerbates ischemia–reperfusion injury. CELL MOL BIOL LETT. 2023 Dec;28(1):1-24  FCM ;  Rat.  
[IF=5.23] Diao, Na, et al. "Deficiency in Toll-interacting protein (Tollip) skews inflamed yet incompetent innate leukocytes in vivo during DSS-induced septic colitis."Scientific Reports 6 (2016): 34672.  WB ;  Mouse.  
[IF=4.966] Wenzheng Xia. et al. ANXA1 directs Schwann cells proliferation and migration to accelerate nerve regeneration through the FPR2/AMPK pathway. Faseb J. 2020 Oct;34(10):13993-14005  IHC ;  Rat.  
[IF=4.26] Wang et al. Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells. (2016) Sci.Re. 6:25946  WB, IF(ICC) ;  Rat.  
研究領(lǐng)域 心血管  細(xì)胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞粘附分子  G蛋白偶聯(lián)受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 39kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FPRL1: 51-150/351 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 FPRL1 is a low affinity receptor to N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). FPRL1 has been reported in phagocytes, monocytes, neutrophils, differentiated myeloid cells from bone marrow, granulocyte HL-60 cells, and synovial fibroblasts. ESTs have been isolated from blood, leukocyte, lung, and placenta libraries.

Function:
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P25090

Gene ID:
2358

Database links:

Entrez Gene: 2358 Human

Omim: 136538 Human

SwissProt: P25090 Human

Unigene: 99855 Human



脂氧素受體廣泛表達(dá)于各類炎癥相關(guān)細(xì)胞并受多種炎癥刺激的調(diào)節(jié),通過PKA、PKC、MAPK等一系列信號途徑參與控制炎癥的發(fā)生發(fā)展。
產(chǎn)品圖片
Sample: SW480(Human) Cell Lysate at 30 ug LOVO(Human) Cell Lysate at 30 ug Primary: Anti-FPRL1 (bs-3654R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kD Observed band size: 39 kD
Sample:Liver(Mouse) Lysate at 40 ug Primary: Anti-FPRL1(bs-3654R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kD Observed band size: 47 kD
Sample: Bone (Mouse) Lysate at 40 ug Primary: Anti- FPRL1 (bs-3654R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kD Observed band size: 39 kD
Sample: Lane 1: U937 (Human) Cell Lysate at 30 ug Lane 2: HL60 (Human) Cell Lysate at 30 ug Lane 3: Hela (Human) Cell Lysate at 30 ug Lane 4: HepG2 (Human) Cell Lysate at 30 ug Lane 5: SW480 (Human) Cell Lysate at 30 ug Lane 6: Lovo (Human) Cell Lysate at 30 ug Primary: Anti-FPRL1 (bs-3654R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kD Observed band size: 35 kD
Sample: kidney (Mouse) Lysate at 40 ug Primary: Anti-FPRL1 (Bs-3654R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kD Observed band size: 48 kD
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