| 產(chǎn)品編號 | bs-4040R |
| 英文名稱 | Rabbit Anti-IL18BP antibody |
| 中文名稱 | 白細(xì)胞介素18結(jié)合蛋白抗體 |
| 別 名 | IL18 BP; IL18 BPa; IL18BP; IL18BPa; Interleukin 18 binding protein; Tadekinig alfa; I18BP_HUMAN; IL-18BP; Interleukin-18-binding protein |
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Specific References (2) | bs-4040R has been referenced in 2 publications.
[IF=5.41] Businaro, Rita, et al. "Interleukin-18 modulation in autism spectrum disorders." Journal of Neuroinflammation 13.1 (2016): 2. WB ; Mouse.
[IF=5.102] Serafino Ricci 2016-01-05. (2016) J.Neuroinflammation. http://www.jneuroinflammation.com/content/13/1/2 WB ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 結(jié)合蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human,Pig,Cow) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 18kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IL18BP: 91-194/194 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
IL18 binding protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18 induced IFN gamma production. It is constitutively expressed and secreted in mononuclear cells and can be enhanced by IFN gamma. An elevated level of this protein is detected in the intestinal tissues of patients with Crohn disease. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. Function: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. Subcellular Location: Secreted. Tissue Specificity: Strongly expressed in heart, lung, placenta and spleen. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. SWISS: O95998 Gene ID: 10068 Database links: Entrez Gene: 10068 Human Omim: 604113 Human SwissProt: O95998 Human Unigene: 591967 Human Unigene: 20083 Rat |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Mouse Lymph node tissue lysates
Lane 2: Mouse Placenta tissue lysates
Lane 3: Mouse Large intestine tissue lysates
Lane 4: Rat Lymph node tissue lysates
Lane 5: Rat Lung tissue lysates
Lane 6: Rat Placenta tissue lysates
Lane 7: Rat Large intestine tissue lysates
Primary: Anti-IL18BP (bs-4040R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 18 kDa
Observed band size: 52 kDa
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