| 產(chǎn)品編號 | bs-4509R |
| 英文名稱 | CXCL13/BCA1 Rabbit pAb |
| 中文名稱 | B-淋巴細胞趨化因子抗體 |
| 別 名 | C-X-C motif chemokine 13; Angie; ANGIE; ANGIE2; B cell-attracting chemokine 1; B cell attracting chemokine 1; B lymphocyte chemoattractant; B-cell chemoattractant; B-cell-attracting chemokine 1; B-cell-homing chemokine(ligand for Burkitt's lymphoma receptor-1); CXL13_MOUSE; BCA-1; BLC; BLR1L; Chemokine(C-X-C motif) ligand 13; Chemokine(C-X-C motif) ligand 13(B-cell chemoattractant); Chemokine, CXC motif, ligand 13; CXC chemokine BLC; CXCL13; SCYB13; Small inducible cytokine B subfamily(Cys-X-Cys motif), member 13(B-cell chemoattractant); Small-inducible cytokine B13; Small inducible cytokine B13; Small inducible cytokine subfamily B, member 13. |
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Specific References (4) | bs-4509R has been referenced in 4 publications.
[IF=39.235] Doloff, Joshua C., et al. "Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates." Nature Materials (2017). WB ; Mouse&Monkey.
[IF=5.215] Tianrui Zhang. et al. Daphnetin Improves Neuropathic Pain by Inhibiting the Expression of Chemokines and Inflammatory Factors in the Spinal Cord and Interfering with Glial Cell Polarization. PHARMACEUTICALS-BASE. 2023 Feb;16(2):243 WB ; Rat.
[IF=2.94] Wang, Lifang, et al. "Chemokine CXCL13 expression was up-regulated in Clostridium difficile infection." Cytokine 88 (2016): 232-240. WB, IHC-P ; Mouse.
[IF=2.52] Expression?of?Pref-1?and?Related?Chemokines?during theDevelopment of Rat Mesenteric Lymph Nodes.(2018)Biomed Environ Sci.ul;31(7):507-514. IHC ; Rat.
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| 研究領(lǐng)域 | 細胞生物 免疫學(xué) 趨化因子 b-淋巴細胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=1ug/Test
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 10 kDa |
| 檢測分子量 | |
| 細胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse CXCL13/BCA1: 23-109/109 |
| 亞 型 | |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
B lymphocyte chemoattractant, independently cloned and named Angie, is a CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR1). It may therefore function in the homing of B lymphocytes to follicles. Function: Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs. Subcellular Location: Secreted. Tissue Specificity: Found in spleen (B-cell-rich zone or follicles), Peyer patches (strongest within germinal centers and extending to the mantle zone) and lymph nodes (in reticular pattern in follicles). Similarity: Belongs to the intercrine alpha (chemokine CxC) family. SWISS: O55038 Gene ID: 55985 Database links: Entrez Gene: 10563 Human Entrez Gene: 55985 Mouse Omim: 605149 Human SwissProt: O43927 Human SwissProt: O55038 Mouse Unigene: 100431 Human Unigene: 10116 Mouse Unigene: 6917 Rat |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Human Jurkat cell lysates
Primary: Anti-CXCL13 (bs-4509R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 10 kDa
Observed band size: 16 kDa
Paraformaldehyde-fixed, paraffin embedded (human liver carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for
Blank control（black line）:HepG2.
Primary Antibody (green line): Rabbit Anti-CXCL13 antibody (bs-4509R)
Dilution:1ug/Test;
Secondary Antibody（white blue line）: Goat anti-rabbit IgG-AF488
Dilution: 0.5ug/Test.
Isotype control（orange line）: Normal Rabb
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