| 產(chǎn)品編號(hào) | bs-1240G |
| 英文名稱(chēng) | human Fibrinogen Goat pAb |
| 中文名稱(chēng) | 羊抗人纖維蛋白原抗體 |
| 別 名 | FGA; FGA protein; FGB; FGG; Fib2; Fibrin alpha chain; Fibrinogen A alpha polypeptide; Fibrinogen A alpha polypeptide chain; Fibrinogen alpha chain; Fibrinogen B alpha polypeptide; Fibrinogen beta chain; Fibrinogen G alpha polypeptide; Fibrinogen gamma chain; MGC104327; MGC119422; MGC119423; MGC119425; MGC120405; FIBA_HUMAN. |
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Specific References (1) | bs-1240G has been referenced in 1 publications.
[IF=4.882] Li Peichuang. et al. Preparation of phospholipid-based polycarbonate urethanes for potential applications of blood-contacting implants. Regen Biomater. 2020 Oct;7(5):491-504 ELISA ; Rabbit.
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| 研究領(lǐng)域 | 心血管 細(xì)胞生物 |
| 抗體來(lái)源 | Goat |
| 克隆類(lèi)型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 240 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Fibrinogen from human plasma |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Subcellular Location: Secreted. Tissue Specificity: Plasma. Post-translational modifications: The alpha chain is not glycosylated. Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers. About one-third of the alpha chains in the molecules in blood were found to be phosphorylated. Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Phosphorylation sites are present in the extracellular medium. Similarity: Contains 1 fibrinogen C-terminal domain. SWISS: P02671 Gene ID: 2266 Database links: Entrez Gene: 2243 Human Entrez Gene: 2244 Human Entrez Gene: 2266 Human Omim: 134820 Human Omim: 134850 Human SwissProt: P02671 Human Unigene: 351593 Human |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Human Plasma
Lane 2: Human Fibrinogen (from plasma)( bs-1240P)
Primary: Anti-Fibrinogen (bs-1240G) at 1/1000 dilution
Secondary: IRDye800CW Donkey anti-Goat IgG at 1/20000 dilution
Predicted band size: 240 kDa
Observed band size: 55,65,73 kDa
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