国产成人福利久久久_2019色 亚洲 日韩 国产 在线_免费在线观看黄色视频亚洲不卡_综合自拍三级欧美_久久精品高清最新地址无码_成人网站在线下载_精品电影日韩亚洲_麻豆影院无码一级_欲妇的爆乳大肉臀小说_在线看亚洲十八禁网

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
好看的言情小说,古风名字
首頁 > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
NEK8 Rabbit pAb (bs-7815R)  
訂購熱線:400-901-9800
訂購郵箱:[email protected]
訂購QQ:  400-901-9800
技術支持:[email protected]
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產(chǎn)品編號 bs-7815R
英文名稱 NEK8 Rabbit pAb
中文名稱 絲氨酸/蘇氨酸蛋白激酶NEK8抗體
別    名 JCK; NEK 8; NEK12A; NEK8; NEK8_HUMAN; Never in mitosis A-related kinase 8; NIMA-family kinase NEK8; NIMA-related kinase 12a; Nima-related protein kinase 12a; NimA-related protein kinase 8; Serine/threonine-protein kinase Nek8.  
研究領域 細胞生物  細胞周期蛋白  激酶和磷酸酶  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat,Cow,Chicken,Dog)
產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 75 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NEK8: 101-200/692 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Required for renal tubular integrity.
Tissue specificity: Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma.

Function:
Required for renal tubular integrity. May regulate localcytoskeletal structure in kidney tubule epithelial cells. Mayregulate ciliary biogenesis through targeting of proteins to thecilia (By similarity).

Subunit:
Interacts with PKD2; may regulate PKD2 targeting to thecilium (By similarity).

Subcellular Location:
Cytoplasm (By similarity). Cytoplasm,cytoskeleton. Cell projection, cilium (By similarity).Note=Predominantly cytoplasmic. Localizes to the proximal region ofthe primary cilium and is not observed in dividing cells.

Tissue Specificity:
Highest expression in thyroid, adrenal glandand skin. Low levels in spleen, colon and uterus. Overexpressed inbreast tumors, with highest expression in infiltrating ductalcarcinomas and moderate levels in mucinous adenocarcinoma.

DISEASE:
Defects in NEK8 are the cause of nephronophthisis type 9(NPHP9) [MIM:613824]. NPHP9 is an autosomal recessive disorderresulting in end-stage renal disease. It is a progressivetubulo-interstitial kidney disorder histologically characterized bymodifications of the tubules with thickening of the basementmembrane, interstitial fibrosis and, in the advanced stages,medullary cysts.

Similarity:
Belongs to the protein kinase superfamily. NEK Ser/Thrprotein kinase family. NIMA subfamily.
Contains 1 protein kinase domain.
Contains 5 RCC1 repeats.

SWISS:
Q86SG6

Gene ID:
284086

Database links:
UniProtKB/Swiss-Prot: Q86SG6.1

版權所有 2004-2026 ourmotor168.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號