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Rabbit Anti-RILPL2  antibody (bs-11944R)  
訂購熱線:400-901-9800
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技術(shù)支持:[email protected]
說明書: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)

產(chǎn)品編號(hào) bs-11944R
英文名稱 Rabbit Anti-RILPL2  antibody
中文名稱 Rab溶酶體相互作用蛋白樣2抗體
別    名 FLJ30380; FLJ32372; MGC7036; p40phox-binding protein; Rab-interacting lysosomal protein-like 2; RILP-like protein 2; RILPL2; RIPL2_HUMAN; RLP2; Rab interacting lysosomal protein-like 2.  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞骨架  G蛋白信號(hào)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,Rat (predicted: Human,Pig,Sheep,Cow,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 24kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RILPL2: 111-211/211 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 RILPL2 is a 211 amino acid protein that belongs to the RILPL family. RILPL2 does not regulate lysosomal morphology or distribution. RILPL2 shares 32% and 18% amino acid identity with RILPL1 and RILP, respectively. RILPL2 as a novel interacting partner for the actin-based molecular motor MyoVa, and has a novel role for RILPL2 in controlling neuronal morphogenesis. It has been suggested that there is also a novel role for RILPL2 in the regulation of cellular shape and dendritic-spine morphogenesis, probably via the Rac1-Pak pathway. PCR analysis of human tissues detects highest RILPL2 expression in lung, followed by placenta. Lower expression is detected in liver, kidney, pancreas, heart and brain, but no expression is detected in skeletal muscle. The RILPL2 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken and zebrafish, and maps to human chromosome 12q24.31.

Function:
Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. May activate RAC1

Subunit:
Interacts (via N-terminus) with MYO5A, the interaction is required for its role in dendrite formation. Interacts with RAC1 (By similarity).

Subcellular Location:
Cytoplasm

Tissue Specificity:
Widely expressed. Expressed at higher level in lung.

Similarity:
Belongs to the RILPL family.
Contains 1 RILP-like domain.

SWISS:
Q969X0

Gene ID:
196383

Database links:

Entrez Gene: 196383 Human

Omim: 614093 Human

SwissProt: Q969X0 Human

Unigene: 488173 Human



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded Mouse Kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with RILPL2 Polyclonal Antibody, Unconjugated (bs-11944R) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit, SP-0023) and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Rat Kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with RILPL2 Polyclonal Antibody, Unconjugated (bs-11944R) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit, SP-0023) and DAB (C-0010) staining.
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