| 產(chǎn)品編號 | bs-13537R |
| 英文名稱 | Rabbit Anti-GPR44 antibody |
| 中文名稱 | G蛋白偶聯(lián)受體44抗體 |
| 別 名 | GPCR GPR44; CD294; CD 294; CD294 antigen; Chemoattractant receptor homologous molecule expressed on Th2 cells; chemoattractant receptor-homologous; Chemoattractant receptor-homologous molecule expressed on Th2 cells; CRTH 2; CRTH2; DL1R; DP2 prostaglandin receptor; G Protein Coupled Receptor 44; GPR 44; Gpr44; PD2R2_HUMAN; PTGDR2; Putative G protein coupled receptor 44; Putative G-protein coupled receptor 44; GPCR 44. |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) G蛋白偶聯(lián)受體 G蛋白信號 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 43kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPR44/CD294: 121-220/395 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The human chemoattractant receptor-homologous molecule (CRTH2, GPR44, G protein-coupled receptor 44) maps to chromosome 11q12-q13.3 and encodes a 472 amino acid G protein-coupled leukocyte chemoattractant receptor. Chemoattractant receptors present on Th2 cells respond to parasites and play a central role in allergic inflammation; they are absent on type 1 T helper (Th1) cells, which address intracellular bacteria and many viruses. CRTH2 contains seven putative transmembrane domains and mediates signals to the interior of the cell upon exposure to its cognate ligand prostaglandin (PG) D2, which is able to attract basophils, eosinophils, type 2 Th (Th2) cells and type 2 cytotoxic (Tc2) CD8+ T lymphocytes. CRTH2 expression on active Th2 cells influences supportive roles in Th2-type immune reactions. 3.5 kb CRTH2 transcripts are present in thalamus, frontal cortex, pons, hippocampus, hypothalamus and caudate, while 3.4 kb transcripts are present in fetal liver, leukocytes and thymus. Function: Orphan receptor. Subcellular Location: Cell membrane. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: Q9Y5Y4 Gene ID: 11251 Database links: Entrez Gene: 11251 Human Omim: 604837 Human SwissProt: Q9Y5Y4 Human Unigene: 299567 Human |
| 產(chǎn)品圖片 |
Sample:
293T(Human) Cell Lysate at 30 ug
HepG2(Human) Cell Lysate at 30 ug
Primary: Anti-GPR44 (bs-13537R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 43 kD
Observed band size: 53 kD
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