| 產(chǎn)品編號(hào) | bs-13865R |
| 英文名稱 | Rabbit Anti-CEP95 antibody |
| 中文名稱 | 中心體蛋白95抗體 |
| 別 名 | CCDC45; Centrosomal protein 95kDa; Centrosomal protein of 95 kDa; Cep95; CEP95_HUMAN; Coiled coil domain containing 45; Coiled-coil domain-containing protein 45. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 細(xì)胞分化 表觀遺傳學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 95kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CEP95: 751-821/821 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The coiled-coil domain is a structural motif found in proteins that are involved in a diverse array of biological functions such as the regulation of gene expression, cell division, membrane fusion and drug extrusion and delivery. CCDC45 (coiled-coil domain containing 45) is a 821 amino acid protein encoded by a gene that maps to human chromosome 17q23.3. Chromosome 17 comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Subcellular Location: Cytoplasm; cytoskeleton; centrosome. Cytoplasm ; cytoskeleton; spindle pole. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. SWISS: Q96GE4 Gene ID: 90799 Database links: Entrez Gene: 90799 Human Entrez Gene: 320162 Mouse SwissProt: Q96GE4 Human SwissProt: Q8BVV7 Mouse Unigene: 569713 Human |
| 產(chǎn)品圖片 |
Sample:
MCF-7 (Human) Cell Lysate at 40 ug
Lovo (Human) Cell Lysate at 40 ug
Primary: Anti-CEP95(bs-13865R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 95kD
Observed band size: 95kD
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