| 產(chǎn)品編號(hào) | bs-10576R |
| 英文名稱 | Rabbit Anti-IL24 antibody |
| 中文名稱 | 白介素-24抗體 |
| 別 名 | IL24_HUMAN; Interleukin-24; IL-24; Melanoma differentiation-associated gene 7 protein; MDA-7; Suppression of tumorigenicity 16 protein. |
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Specific References (2) | bs-10576R has been referenced in 2 publications.
[IF=3.202] Yang M et al. Combination therapy with F5/35 fiber chimeric conditionally replicative adenoviruses expressing IL-24 enhances the antitumor effect of temozolomide against melanoma. (2018)Cancer Medicine. Dec;7(12):5928-5942. WB&ICC ;
[IF=1.482] Liang et al. A conditionally replicating adenovirus expressing IL-24 acts synergistically with temozolomide to enhance apoptosis in melanoma cells in vitro. (2017) Oncol.Let. 13:4185-4189 WB ; Human.
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| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 細(xì)胞因子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 17kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IL24: 121-206/206 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Function: Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation. Subcellular Location: Secreted (Potential). Tissue Specificity: Up-regulated in melanoma cells induced to terminally differentiate. Similarity: Belongs to the IL-10 family. SWISS: Q13007 Gene ID: 11009 Database links: Entrez Gene: 11009 Human Omim: 604136 Human SwissProt: Q13007 Human Unigene: 58831 Human Unigene: 728324 Human |
| 產(chǎn)品圖片 |
Sample:
Jurkat (human)cell Lysate at 40 ug
Primary: Anti- IL-24 (bs-10576R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 17 kD
Observed band size: 17 kD
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