| 產(chǎn)品編號(hào) | bs-19556R |
| 英文名稱 | Rabbit Anti-NXT1 antibody |
| 中文名稱 | 核運(yùn)輸因子1抗體 |
| 別 名 | MTR2; MTR2, yeast, homolog of; NTF2 like export factor 1; NTF2 related export protein 1; NTF2-related export protein 1; NUTF like export factor 1; NXT1; NXT1_HUMAN; P15; Protein P15. |
| 研究領(lǐng)域 | 染色質(zhì)和核信號(hào) 信號(hào)轉(zhuǎn)導(dǎo) 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 16kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NXT1: 51-140/140 |
| 亞 型 | |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008] Function: Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with THOC4 and THOC5. Subcellular Location: Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Similarity: Contains 1 NTF2 domain. SWISS: Q9UKK6 Gene ID: 29107 Database links: Entrez Gene: 29107 Human Entrez Gene: 56488 Mouse Omim: 605811 Human SwissProt: Q9UKK6 Human SwissProt: Q9QZV9 Mouse Unigene: 516933 Human Unigene: 34663 Mouse Unigene: 8541 Rat |
