| 產(chǎn)品編號 | bs-20838R |
| 英文名稱 | Rabbit Anti-LY6E antibody |
| 中文名稱 | T淋巴細(xì)胞激活蛋白6E抗體 |
| 別 名 | Ly-6E ; LY6E_HUMAN ; LY6E_MOUSE ; Lymphocyte antigen 6E ; Retinoic acid-induced gene E protein ; RIG-E ; RIGE; SCA2; TSA1; 9804; SCA-2 ; Stem cell antigen 2 ; Thymic shared antigen 1 ; TSA-1 . |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 干細(xì)胞 淋巴細(xì)胞 t-淋巴細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 14kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse LY6E: 31-80/136 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene belongs to the human Ly6 gene family and encodes a glycosylphosphatidyl-inositol (GPI)-anchored cell surface protein. The protein plays an important role in T cell physiology, oncogenesis and immunological regulation. The protein is also involved in modulation of viral infection by coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2021] Function: GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation (By similarity). Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion (PubMed:32641482). Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (By similarity). Tissue Specificity: Widely expressed, predominantly in liver, kidney, ovary, spleen and peripheral blood Leukocytes. Similarity: Contains 1 UPAR/Ly6 domain. SWISS: Q64253 Gene ID: 17069 Database links: Entrez Gene: 17069 Mouse SwissProt: Q64253 Mouse Unigene: 788 Mouse Unigene: 3321 Rat |
| 產(chǎn)品圖片 |
Sample:Thymus (Mouse)Lysate at 40 ug
Primary: Anti-LY6E(bs-20838R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 14kD
Observed band size: 14kD
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