| 產(chǎn)品編號 | bs-22173R |
| 英文名稱 | PINK1 Rabbit pAb |
| 中文名稱 | 絲氨酸/蘇氨酸蛋白激酶PINK1抗體 |
| 別 名 | PINK1_HUMAN; PTEN Induced Putative Kinase 1; PTEN-Induced Putative Kinase Protein 1; BRPK; Serine/Threonine-Protein Kinase PINK1, Mitochondrial; Parkinson Disease(Autosomal Recessive) 6; Protein Kinase BRPK; EC 2.7.11.1; PARK6; |
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Specific References (1) | bs-22173R has been referenced in 1 publications.
[IF=4.109] Yihui Huo. et al. Exposure to copper activates mitophagy and endoplasmic reticulum stress-mediated apoptosis in chicken (Gallus gallus) cerebrum. ENVIRON TOXICOL. 2022 Nov;: WB ; Chicken.
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| 研究領(lǐng)域 | 腫瘤 心血管 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 激酶和磷酸酶 線粒體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 64 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 線粒體 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PINK1: 441-540/581 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008] Function: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitement to dysfunctional mitochondria to initiate their degradation. Subunit: Interacts with PRKN. Interacts with FBXO7. Forms a complex with PRKN and PARK7 (PubMed:19229105). Subcellular Location: Mitochondrion outer membrane. Cytoplasm > cytosol. Tissue Specificity: Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development. Post-translational modifications: Autophosphorylated. DISEASE: Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6) [MIM:605909]. A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep. Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain. SWISS: Q9BXM7 Gene ID: 65018 Database links:
Entrez Gene: 65018 Human
Entrez Gene: 68943 Mouse NCBI: 14165272 Human Omim: 608309 Human SwissProt: Q9BXM7 Human SwissProt: Q99MQ3 Mouse Unigene: 389171 Human Unigene: 18539 Mouse Unigene: 219286 Rat |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Human HeLa cell lysates
Lane 2: Human A431 cell lysates
Lane 3: Human U-2OS cell lysates
Primary: Anti- PINK1 (bs-22173R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 64 kDa
Observed band size: 60 kDa
Sample:
Lane 1: Mouse Muscle tissue lysates
Lane 2: Mouse Cerebrum tissue lysates
Lane 3: Rat Heart tissue lysates
Lane 4: Rat Muscle tissue lysates
Lane 5: Rat Cerebrum tissue lysates
Lane 6: Human U-2 OS cell lysates
Primary: Anti-PINK1 (bs-22173R) at 1/500 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 64 kDa
Observed band size: 58 kDa
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