| 產(chǎn)品編號 | bs-22415R |
| 英文名稱 | Rabbit Anti-KIF18B antibody |
| 中文名稱 | 驅(qū)動(dòng)蛋白家族成員18B抗體 |
| 別 名 | Kinesin family member 18B; KI18B_HUMAN; Kinesin-like protein KIF18B. |
| 研究領(lǐng)域 | 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 細(xì)胞分化 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat (predicted: Human,Mouse,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 94kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KIF18B : 121-220/864 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The Kinesins constitute a large family of microtubule-dependent motor proteins which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual Kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events, including endocytosis and transcytosis. KIF18B (kinesin family member 18B) is an 864 amino acid nuclear and cytoplasmic protein that belongs to the kinesin-like protein family. Containing one kinesin-motor domain, KIF18B is dominantly expressed in amygdala. During mitosis, KIF18B is suggested to be closely associated with astral microtubules emanating from the spindle pole during prometaphase and metaphase. KIF18B may play an important role in regulating cell division. KIF18B exists as four alternatively spliced isoforms and is encoded by a gene located on human chromosome 17q21.31. Function: May play an important role in regulating cell division. Subunit: Interacts with MAPRE1; this interaction is required for efficient accumulation at microtubule plus ends. Interacts with KIF2C at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. KIF2C phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding. Subcellular Location: Cytoplasmic, Nuclear and Plasma membrane Tissue Specificity: Shows a prominent expression in the amygdala. Similarity: Belongs to the kinesin-like protein family. Contains 1 kinesin-motor domain. SWISS: Q86Y91 Gene ID: 146909 Database links: Entrez Gene: 146909 Human Omim: 614570 Human SwissProt: Q86Y91 Human |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (rat lymphoid); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (KIF18B) Polyclonal Antibody, Unconjugated (bs-22415R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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