| 產(chǎn)品編號(hào) | bsm-51545M |
| 英文名稱 | Mouse Anti-LRRK2 antibody |
| 中文名稱 | 富亮氨酸重復(fù)激酶2單克隆抗體 |
| 別 名 | Dardarin; Leucine rich repeat kinase 2; LRRK 2; LRRK-2; PARK 8; PARK8; ROCO 2; ROCO-2; ROCO2; Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin; LRRK2_HUMAN; augmented in rheumatoid arthritis 17; AURA17; Leucine rich repeat kinase 2; RIPK7. |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) |
| 抗體來源 | Mouse |
| 克隆類型 | Monoclonal |
| 克 隆 號(hào) | L2F6 |
| 交叉反應(yīng) | Human,Mouse |
| 產(chǎn)品應(yīng)用 | WB=1:500-1000,IHC-P=1:100-500,IHC-F=1:400-800,IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 286kDa |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Recombinant human PARK8 (LRRK2) (Fragment) (His-tagged). |
| 亞 型 | IgG1 |
| 純化方法 | affinity purified by Protein G |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
LRRK2 (Dardarin) is encoded by the gene LRRK2. Genetic mutations of LRRK2 have been linked to Parkinsonism and synucleinopathies. LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains. Function: May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Subcellular Location: Cytoplasm. Membrane. Mitochondrion. Localized in the cytoplasm and associated with cellular membrane structures. Associates with the mitochondrial outer membrane. Tissue Specificity: Expressed throughout the adult brain, but at a lower level than in heart and liver. Also expressed in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas. DISEASE: Defects in LRRK2 are the cause of Parkinson disease type 8 (PARK8) [MIM:607060]. A slowly progressive neurodegenerative disorder characterized by bradykinesia, rigidity, resting tremor, postural instability, neuronal loss in the substantia nigra, and the presence of neurofibrillary MAPT (tau)-positive and Lewy bodies in some patients. Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Contains 12 LRR (leucine-rich) repeats. Contains 1 protein kinase domain. Contains 1 Roc domain. SWISS: Q5S007 Gene ID: 120892 Database links: Entrez Gene: 120892 Human SwissProt: Q5S007 Human |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Mouse brain tissue lysates
Primary: Anti-LRRK2 (bsm-51545M) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 286 kD
Observed band size: 200 kD
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