| 產(chǎn)品編號(hào) | bsm-60429R |
| 英文名稱(chēng) | ABCB11 Recombinant Rabbit mAb |
| 中文名稱(chēng) | 膽汁酸鹽輸出泵重組兔單抗 |
| 別 名 | ABCBB_HUMAN; Bile salt export pump; BSEP; EC:7.6.2.-; ATP-binding cassette sub-family B member 11; PGY4; SPGP; ABC16; BRIC2; PFIC2; PFIC-2; |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Recombinant |
| 克 隆 號(hào) | G8A8 |
| 交叉反應(yīng) | Human (predicted: Mouse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-1:1000,IHC-P=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 146 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008] Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ. Database links: Entrez Gene: 8647 Human Entrez Gene: 27413 Mouse SwissProt: O95342 Human SwissProt: Q9QY30 Mouse 催化主要的疏水性膽汁鹽（例如?；撬岷透拾彼峋Y合的膽酸）以ATP依賴(lài)性方式穿過(guò)肝細(xì)胞的小管膜，因此參與肝膽汁酸的穩(wěn)態(tài)，因此通過(guò)調(diào)節(jié)膽汁脂質(zhì)的分泌參與脂質(zhì)的穩(wěn)態(tài) 以膽汁鹽依賴(lài)的方式。 ?；撬峤Y(jié)合的膽汁鹽比甘氨酸結(jié)合的膽汁鹽更快地運(yùn)輸。 |
| 產(chǎn)品圖片 |
Blocking buffer: 5% NFDM/TBST
Primary ab dilution: 1:1000
Primary ab incubation condition: 2 hours at room temperature
Secondary ab: Goat Anti-Rabbit IgG H&L (HRP)
Lysate: 1: Jurkat, 2: HepG2, 3: A549, 4: LNCaP, 5: Mouse liver
Protein loading quantity: 20 μg
Exposure time: 60 s
Predicted MW: 146 kDa
Observed MW: 146 kDa
Tissue: Human liver
Section type: Formalin fixed & Paraffin -embedded section
Retrieval method: High temperature and high pressure
Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:500
Primary ab incubation condition: 1 hour at room temperature
Secondary ab: SP Kit(Rabbit) (sp-0023)
Counter stain: Hematoxylin (Blue)
Comment: Color brown is the positive signal for bsm-60429R
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