| 產(chǎn)品編號(hào) | bsm-34247R |
| 英文名稱 | Neurokinin 1 Receptor Recombinant Rabbit mAb |
| 中文名稱 | P物質(zhì)受體重組兔單克隆抗體 |
| 別 名 | Neurokinin 1; Neurokinin 1 Receptor; NK 1 receptor; NK 1R; NK1 receptor; NK-1R; NK1R; NKIR; SPR; Substance P receptor; TAC 1R; TAC1R; Tachykinin 1 receptor; Tachykinin receptor 1; Tachykinin receptor 1; TACR1. |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Recombinant |
| 克 隆 號(hào) | 12C15 |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 45 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Neurokinin 1 Receptor |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008] Function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. Subunit: Interacts with ARRB1 Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P25103 Gene ID: 6869 Database links: Entrez Gene: 6869 Human Entrez Gene: 21336 Mouse Omim: 162323 Human SwissProt: P25103 Human SwissProt: P30548 Mouse Unigene: 633301 Human Unigene: 8055 Mouse Unigene: 89609 Rat 此抗體與大、小鼠、及豚鼠均有交叉反應(yīng)。P物質(zhì)是由11個(gè)氨基酸組成的多肽，主要分布于感覺(jué)神經(jīng)纖維、后根神經(jīng)節(jié)和脊髓后角，作為重要的神經(jīng)遞質(zhì)或調(diào)制因子參與傷害性刺激的傳遞，該遞質(zhì)與突觸后膜上P物質(zhì)受體結(jié)合，將痛沖動(dòng)傳入中樞，產(chǎn)生疼痛反應(yīng)。 P物質(zhì)與神經(jīng)源性炎癥、瘙癢及疼痛的產(chǎn)生有關(guān)，通過(guò)刺激肥大細(xì)胞釋放組織胺、緩激肽及前列腺素等致炎、致敏、致痛物質(zhì)，引起一系列病理反應(yīng)，P物質(zhì)除作為傷害性信息的信使外，本身又為炎癥介質(zhì)。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Human SH-SY5Y cell lysates
Lane 2: Human U251 cell lysates
Lane 3: Human HeLa cell lysates
Lane 4: Human K562 cell lysates
Primary: Anti-Neurokinin 1 Receptor (bsm-34247R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 45 kDa
Observed band size: 46 kDa
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