| 產(chǎn)品編號(hào) | bsm-52553R |
| 英文名稱 | PYK2 Recombinant Rabbit mAb |
| 中文名稱 | 富含脯氨酸的酪氨酸激酶2重組兔單克隆抗體 |
| 別 名 | CADTK; CAK beta; CAKB antibody; CAKbeta; Calcium dependent tyrosine kinase; Calcium-dependent tyrosine kinase; Cell adhesion kinase beta; E430023O05Rik; EC 2.7.10.2; FADK 2; FADK2; FAK 2; FAK1; FAK2; Focal Adhesion Kinase 2; MGC124628; PKB; pp125FAK; Prol |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | 7H4 |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:20-100,IHC-F=1:20-100,IF=1:20-100,Flow-Cyt=1:20-50,ICC/IF=1:20-100
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 116 kDa |
| 檢測(cè)分子量 | |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Human PYK2 between 1-100 amino acids |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] SWISS: Q14289 Gene ID: 2185 富含脯氨酸的酪氨酸激酶 2 (protein richtyro sinekinase 2 ,PYK2 ) ,又稱細(xì)胞粘附激酶β(cellularadhesionkinaseβ ,CAKβ)、相關(guān)粘附聚焦酪氨酸激酶(relatedadhesionfocaltyrosinekinase ,RAFTK) ,是粘著斑激酶 (focaladhesionkinase,FAK)家族的成員之一。PYK2是FAK家族的成員之一 ,是一種鈣依賴性酪氨酸激酶 ,在氨基酸序列上與FAK有 4 5 %的同源性。它的活化涉及了多條信 |
