| 產(chǎn)品編號(hào) | D62067 |
| 英文名稱 | CBL0137 |
| 中文名稱 | |
| 別 名 | CBLC137; Curaxin 137 |
| 克 隆 號(hào) | |
| CAS | 1197996-80-7 |
| 理論分子量 | 336.4 kDa |
| 保存條件 | -20℃ |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
CBL0137, a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates the efficacy of gemcitabine in preClinicalal models of pancreatic cancer. |
