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Nestin Mouse mAb (bsm-55556M)  
訂購熱線:400-901-9800
訂購郵箱:[email protected]
訂購QQ:  400-901-9800
技術(shù)支持:[email protected]
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)

產(chǎn)品編號 bsm-55556M
英文名稱 Nestin Mouse mAb
中文名稱 巢蛋白/神經(jīng)上皮干細(xì)胞蛋白單克隆抗體
別    名 ESTM 46; FLJ 21841; FLJ21841; Intermediate filament protein; Nbla00170; Nes; NEST_HUMAN; Nestin.  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號
交叉反應(yīng) Rat
產(chǎn)品應(yīng)用 IHC-P=1:50-200,IHC-F=1:50-200,IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 208 kDa
檢測分子量
細(xì)胞定位 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 Recombinant protein corresponding to Mouse Nestin 
亞    型 IgG2b,κ
純化方法 affinity purified by Protein A
緩 沖 液 PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Nestin is a Class VI intermediate filament expressed in the developing central nervous system (CNS) in early embryonic neuroepithelial stem cells. This protein has been widely used as a predominant marker for stem / progenitor cells, glioma cells, and tumor endothelial cells in the mammalian CNS. Furthermore, it is a superior angiogenic marker to evaluate neovascularity of endothelial cells in tumor.

Function:
Required for brain and eye development (By similarity). Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.

Subunit:
Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, this protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%. Interacts with FHOD3.

Subcellular Location:
cytoplasm

Tissue Specificity:
CNS stem cells.

Post-translational modifications:
Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized.

Similarity:
Belongs to the intermediate filament family.

SWISS:
Q6P5H2

Gene ID:
18008

Database links:

Entrez Gene : 10763 Human

Entrez Gene : 18008 Mouse

Entrez Gene : 25491 Rat

Omim : 600915 Human

SwissProt : P48681 Human

SwissProt : Q6P5H2 Mouse

SwissProt : P21263 Rat

Unigene : 527971 Human

Unigene : 331129 Mouse

Unigene : 9701 Rat



神經(jīng)干細(xì)胞標(biāo)志物 在動物體早期發(fā)育過程中,中樞神經(jīng)系統(tǒng)發(fā)育尤為重要 。Nestin是一種中等纖維蛋白,它在哺乳動物神經(jīng)前體細(xì)胞中表達(dá)較高,目前已被廣泛用于神經(jīng)前體細(xì)胞的重要標(biāo)志分子。研究Nestin的表達(dá)調(diào)控規(guī)律,將有助于人們認(rèn)識神經(jīng)前體細(xì)胞的生物特性。此抗體還表達(dá)中樞神經(jīng)系統(tǒng)干細(xì)胞及神經(jīng)上皮細(xì)胞。
產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded Rat Kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Nestin Monoclonal Antibody, Unconjugated(bsm-55556M) at 1:200 overnight at 4°C, followed by conjugation to the bs-40296G-HRP and DAB (C-0010) staining.
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