| 產(chǎn)品編號(hào) | bsm-63282R |
| 英文名稱 | phospho-Tau (S356) Recombinant Rabbit mAb |
| 中文名稱 | 磷酸化微管相關(guān)蛋白重組兔單抗 |
| 別 名 | DDPAC; MAPT; MAPTL; MSTD; Mtapt; MTBT1; MTBT2; PHF tau; PPND; pTau; RNPTAU; TAU. |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | 4C2 |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 79 kDa |
| 檢測(cè)分子量 | 50-70 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human Tau around the phosphorylation site of S356: SKIG-pS-LDN |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. SWISS: P10636 Gene ID: 4137 tau蛋白是腦內(nèi)神經(jīng)元細(xì)胞支架蛋白之一.其正常功能是促進(jìn)微管蛋白組成微管,并維持已形成微管的穩(wěn)定性.參與維持細(xì)胞形態(tài)、信息傳遞、細(xì)胞分裂等重要生物學(xué)過(guò)程,是軸突生長(zhǎng)發(fā)育和神經(jīng)元極性形成的不可缺少因素. 近年來(lái)發(fā)現(xiàn)tau蛋白與一些中樞神經(jīng)系統(tǒng)變性疾病密切相關(guān),尤其是神經(jīng)Tau具有啟動(dòng)微管系統(tǒng)的裝配以及穩(wěn)定微管系統(tǒng)的作用，該蛋白的錯(cuò)誤折疊與老年性癡呆等神經(jīng)退行性疾病密切相關(guān). |
