| 產(chǎn)品編號(hào) | bs-0428R-PE |
| 英文名稱1 | Rabbit Anti-DISC1 (NT)/PE Conjugated antibody |
| 中文名稱 | PE標(biāo)記的DISC1 N端抗體 |
| 別 名 | disrupted in schizophrenia1; C1orf136; KIAA0457; RP4-730B13.1; SCZD9; DISC1; DISC1_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) Alzheimer's |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, (predicted: Human, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 92kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DISC1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: DISC1 (disrupted in schizophrenia 1) is a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. DISC1 is a multifunctional protein that is involved in neurite outgrowth and cortical development, through its interaction with proteins of the centrosome and cytoskeletal system, and is implicated in schizophrenia. Regions of the primate brain which express DISC1, including the hippocampus, lateral septum, amygdala, cerebral cortex, cerebellum and paraventricular hypothalamus, are reported to be involved in schizophrenia in humans. Function: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. Subcellular Location: Cytoplasm. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Colocalizes with PCNT at the centrosome. Tissue Specificity: Ubiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter. DISEASE: Note=A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1;11)(q42.1;q14.3). The truncated DISC1 protein produced by this translocation is unable to interact with ATF4, ATF5 and NDEL1. Genetic variation in DISC1 is associated with susceptibility to schizophrenia type 9 (SCZD9) [MIM:604906]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. Database links: Entrez Gene: 27185 Human Omim: 605210 Human SwissProt: Q9NRI5 Human Unigene: 13318 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. DISC1基因是蛋白質(zhì)復(fù)合體中的一部分,它對(duì)大腦皮層發(fā)育過(guò)程中細(xì)胞的正常運(yùn)動(dòng)很重要。 DISC-1基因的變異增加了患精神分裂癥的風(fēng)險(xiǎn)。研究人員發(fā)現(xiàn)，抑制老鼠的DISC1活性則改變了動(dòng)物大腦的發(fā)育，引起了大腦皮層輕微的變異，而在對(duì)精神分裂癥病人進(jìn)行尸檢時(shí)在其大腦中見(jiàn)到了此變化。研究人員還發(fā)現(xiàn)將DISC1與對(duì)大腦發(fā)育和調(diào)節(jié)神經(jīng)傳遞素水平很重要的分子信號(hào)路徑聯(lián)系起來(lái)，精神病患者的神經(jīng)傳遞素水平往往是不正常的。 新研究顯示DISC1蛋白質(zhì)與一個(gè)叫PDE4B的酶相互作用，而影響信號(hào)傳遞分子cAMP的活性。這個(gè)信號(hào)傳遞系統(tǒng)過(guò)去在其它試驗(yàn)系統(tǒng)中被發(fā)現(xiàn)與學(xué)習(xí)、記憶、以及情緒有關(guān)，這與該系統(tǒng)中的變化可能促成精神分裂癥是一致的。 |
