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Rabbit Anti-Thioredoxin 2/Gold Conjugated antibody (bs-4256R-Gold)
訂購(gòu)熱線(xiàn):400-901-9800
訂購(gòu)郵箱:[email protected]
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:[email protected]
說(shuō) 明 書(shū): 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-4256R-Gold
英文名稱(chēng) Rabbit Anti-Thioredoxin 2/Gold Conjugated antibody
中文名稱(chēng) 膠體金標(biāo)記的線(xiàn)粒體硫氧還蛋白2抗體
別    名 mitochondrial thioredoxin; MT-TRX; MTRX; thioredoxin 2 precursor; Thioredoxin mitochondrial; Thioredoxin2; TRX 2; TRX2; TXN 2; TXN2; THIOM_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul(10nm  15nm  35nm
研究領(lǐng)域 腫瘤  免疫學(xué)  腫瘤細(xì)胞生物標(biāo)志物  新陳代謝  線(xiàn)粒體  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 12kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Thioredoxin 2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide isomerase(PDI) and a number of transcription factors such as p53, NF-kB and AP-1. Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.

Function:
Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity.

Subunit:
Monomer.

Subcellular Location:
Mitochondrion.

Tissue Specificity:
Widely expressed in adult (at protein level) and fetal tissues.

Similarity:
Belongs to the thioredoxin family.
Contains 1 thioredoxin domain.

Database links:

Entrez Gene: 25828 Human

Entrez Gene: 56551 Mouse

Entrez Gene: 79462 Rat

Omim: 609063 Human

SwissProt: Q99757 Human

SwissProt: P97493 Mouse

SwissProt: P97615 Rat

Unigene: 211929 Human

Unigene: 55043 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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